1. Dialectical approach (analysis of the contradictions) inherent in the main tool for solving problems which are ARIZ was distorted by introducing new concepts (technical and physical contradictions.) These new concepts distorts the dialectical contradiction, formulated in a dialectical logic, which led to difficulties in identifying the contradictions in trying to solve with the help of real ARIZ inventive problems.
2. At this should be a separate focus - and what can be considered a real inventive task? As correct or incorrect wording inventive problem may affect the commercialization of inventions arising? And is it possible to reliably protect the solution emerged from unauthorized copying? Finding the answers to these and many other questions are now becoming a major part of the dialectic of creating strategy of patenting and licensing of inventions
As shown, the dialectical analysis in inventions that are created now, and if the authors of these inventions and their logistics partner focused on commercial success, dialectical analysis of the most appropriate conduct in the following order:

• Well-known solution to the problem and their limitations
• Offers an innovative solution to the problem and its advantages
• The state of the project is currently
• Any activity in the development of the project take place in the present,
• Assessment of the applicative potential of the project
• Characteristics of the price factor in the creation of innovative product and its structural and comparative analysis
• Characteristics of potential intellectual property on which the project is based and which can be created as the project
• The intended organizational and structural actions necessary to implement the project
• Assessment of the resources required for the project, evaluation of possible sources of funding
• Proposals for potential cooperation partners

This thesis describes the clear information about which scientific discoveries in this area are initiating in the innovative development

Most clearly shown by information about - what scientific and technical directions deserve the Nobel Prize assignment

In Stockholm, announced the winners of the Nobel Prize in Physiology or Medicine. This year the award was given to John Gardon (Sir John B. Gurdon) and Xingyi Yamanaka (Shinya Yamanaka) for "opening the possibility of reprogramming adult cells into pluripotent." In other words, for obtaining induced pluripotent stem cells. The award ceremony is scheduled for December 10, 2012.
Sir John Gardon - British biologist known for his work on nuclear transfer. He was born in 1933, and in 1960 he graduated from the University of Oxford. Scholar received his doctorate at the California Institute of Technology. In 1962, Gardon conducted an experiment in which replaced the nucleus of a frog egg cell into the nucleus taken from the intestinal cells. Subsequently, from such eggs develop normal tadpoles. The experiment have provided evidence that the specialized cells in the genome contains information sufficient for all cells, and their specialization can be reversible.
Xingyi Yamanaka was born in Osaka in 1962, the year of release of key articles Gardone. He graduated from the University of Kobe, and he defended his doctoral thesis at the University of Osaka in 1993. Research, for which Yamanaka won the Nobel Prize, held 40 years after the experiments Gardone. In 2006, a Japanese scientist and colleagues published a paper in which he showed that activating all four genes in the cells of the connective tissue, they can be turned into stem cells. Subsequently, from such cells can develop any cell in the body.
This year's Nobel Prize in Chemistry for his discovery of the Committee presented a special class of proteins, called GPCR - receptor-related GTPases. For not too clear title hiding proteins that allow us to see, taste and smell, the beating of our hearts tuned to the correct frequency, protect us in times of stress. "Lenta.ru" tried to find out why the prize in chemistry was awarded this year to two cardiologists and what titanic behind this discovery.
In his student Robert Lefkowitz certainly did not dream of the Nobel Prize, at least on the Prize in chemistry. He wanted to be a cardiologist. But fate decreed otherwise, when Lefkowitz graduated, the Vietnam War was in full swing and the young man had to give my duty home in the National Institutes of Health. This major American medical organization, in addition to that includes many hospitals, where patients are treated, is the largest research center not only in medicine, but in general in the area of life sciences
Epinephrine was known to physicians since the late XIX century as a substance that stimulates the heart rate. It is still used in emergency care in the same capacity. There are also physiological effects of intracellular action of adrenaline, and the fact that different cells respond to it in different ways. In accordance with the reaction of the American physiologist Alkvist Raymond (Raymond Ahlquist) suggested that in the body there are two types of receptors that respond to adrenaline - alpha-and beta-receptors. First, in his view, had to be located in the smooth muscle of blood vessels, and the second - in the heart. In a sense, the new work Lefkowitz was indeed associated with cardiology - that the receptors of the heart he had been ordered to find and select.
Such a problem even now is very time consuming and not trivial. It must be understood that there is a fundamental difference in complexity between the selection, for example, myoglobin - cytoplasmic protein cells of the heart - and the receptor of the same cells. Receptor cells in the tens of thousands, millions of times smaller than the structural proteins.
To solve the difficult problem Lefkowitz and his supervisor came up with an original approach - they decided not to provide first receptor, but to prove that it exists, with the use of radioactively labeled hormones. In addition, they focused not on the adrenaline, and the control they hormone - ACTH. Scientists attached to the hormone radioactive isotope of iodine and watched as it binds to the adrenal extract. They also observed, first of all, the displacement of labeled hormone is not labeled and, secondly, the absence of such a displacement outsiders labeled hormone (non-ACTH).
By the time it was already known that the activation of hormone-sensitive cells is accompanied by the appearance in their particular signaling molecule - adezinmonofosfata cyclic monophosphate (cAMP). For its opening Earl Sutherland awarded the Nobel Prize in 1971. That phase enzyme that produces cAMP possible to prove that there is indeed a hormone receptor and binds the labeled hormone and enzyme that produces cAMP.
The results obtained allowed Lefkowitz published in the prestigious journal Science, and get your own lab at Duke University in North Carolina. It was quite an unexpected reward for several years of experiments that yielded no results.
Lefkowitz when it became clear that the dream of becoming a cardiologist is not destined to come true, he dedicated himself to finding and adrenaline receptor gene, which encodes the receptor.
In the early eighties in his lab just came young Dr. Brian Kobilka. He became interested in the mechanism of adrenaline after working in the intensive care unit, where due to hormone injections some patients could literally back to life.
Through the combined efforts and Lefkowitz Kobilke managed to do that could not be very many biochemists - discover the elusive receptor gene adrenaline. To do this, they decided to use affinity chromatography - that is to miss the cellular material through a column packed with sorbent fixed on the hormone. In this receptor binds to the hormone and other proteins can be easily washed away by high salt solution.
History is silent on how many hamsters needed to prepare the extract (receptor isolated from their lungs), but in the end, scientists have been able to get a few micrograms of protein - enough to determine the sequence of the first amino acids. Now that would be enough to find the gene, as genomes of model organisms otsekvenirovany, but in the early 80's it was not so.
In order to "pull out" of the genomic DNA encoding the receptor, the scientists had to carefully calculate what nucleotides can encode several of his well-known amino acids. I must say, the success of scientists must not only perseverance, but also elementary luck, for example, successfully selected detergent or that in receptor gene intron was not accidental - cut sections.
Once the receptor gene sequence was published, it became a sensation. It was found that the receptor of adrenaline - a very specific membrane protein penetrates the cell membrane only seven times (hence the GPCR receptors received its second name - 7TM). Adrenergic receptor structure remarkably resembles the structure of rhodopsin, the light-sensitive enzyme from the retina. When the researchers analyzed the genome for the presence of other similar genes, it became clear that rhodopsin and adrenergic receptor - just a couple of the more than a thousand similar proteins encoded in the human DNA. These receptors are responsible for the perception of odors, light, for taste. It is this structure are dopamine and serotonin receptors, which control health and mood.
Not surprisingly, the discovery immediately interested pharmaceutical companies: picking up the receptors corresponding to "key" can be a specific way to stop their work or, conversely, made to work harder. According to some estimates, about 40 percent of the receptors, which are medications - receptor type GPCR, open and Lefkowitz Kobilkoy.
I must say that the last "hard nut" in the whole system of hormonal signaling was the spatial structure of GPCR. By the mid-seventies, scientists already knew everything about the actual hormones. Studies signaling GTPases (G-proteins) by the time a lot talked about what happens during cell activation by hormones. It became clear that the transfer of the signal activates a cascade, in which the central role is played by cyclic AMP and protein phosphorylation, and in the end the transmitted signal changes gene transcription. For the study of G-proteins, Alfred Gilman and Martin Rodbell received the 1994 Nobel Prize for Physiology or Medicine. Now biologists knowledge on this topic is so increased, which give information about the transmission of signals in cells has become very difficult (for those interested can recommend a very informative lecture itself Lefkowitz). Now unlikely that the full complexity of even the experts are: based on publications in cell signaling component of the volume is a database that sell commercial companies.
Yet, despite the advances in the study of signaling in the cell, the spatial structure of the beta-adrenergic receptor yielded only the efforts of scientists in 2011. And it is able to determine its Kobilke who purposefully went to this for more than twenty years. It is quite possible that this was his last work was the last argument in favor of the award of the Nobel Prize, and Lefkowitz.
Determining the structure - both the question and the fundamental scientific importance, and very specific practical application. On the one hand, the structure helped biologists understand how the binding of hormone receptor activates the GTPase within the cell. On the other hand, it allows the drug companies "molecular docking" - pick up the keys to a small molecule receptor that control its operation. These keys are just in time, with medicines that humanity lacks. It is hoped that scientists who will conduct a "molecular docking", enough perseverance to get the result - as in its time it was enough to scientists who have been awarded the Nobel Prize for Chemistry in 2012.

4. TRIZ has never been found clear mechanisms of transition from conflict to its formulated practical solution. This created serious difficulties in solving real-world problems with ARIZ.
As always has been forced into working order to solve these difficulties, analytical processing of the results can be presented in the form of the following example:
Invented a system of non-contact resonant control of liquids, primarily in the pipeline and process baths or pools
This group of projects has a number of applications that vary in purpose, nature monitored liquids, accuracy, selectivity, integral methods identification signal, the number of stages and stage control, the design features of devices for monitoring, control and configuration of all analytical complex;
The projects in the period of their initial presentation in October 2007 to the present, has come full cycle of experimental and technological test the performance and positive results
Within the specified time studied and passed preliminary tests strategic aspect of this group of projects, in terms of on-line monitoring in real time the presence of toxic substances in drinking water, or unauthorized access of these substances in the main and local water systems;
Within the specified time studied and passed preliminary tests strategic aspect of this group of projects, in terms of on-line monitoring in real-time availability of agricultural pesticides and toxic substances in the process of drinking water or unauthorized entry of these substances into the main and local water systems;
Within the specified time studied and passed preliminary tests strategic aspect of this group of projects, in terms of on-line monitoring in real time the presence of radioactive substances in drinking water, or unauthorized access of these substances in the main and local water systems;
Within the specified time studied and passed preliminary tests strategic aspect of this group of projects, in terms of on-line monitoring in real time the presence of radioactive substances in drinking water in the field, or unauthorized access of these substances as a result of terrorist attacks or technological disasters in the main and local water systems, irrigation systems and water systems of large livestock facilities;
Given the importance for any market for technical and technological security for pipelines for transportation of liquid and gaseous hydrocarbons, the major search conducted test experiments and studies that determine the ability to provide the full range of control - analytical functions in the framework of this process;
In tests used laboratory complexes, assembled in clean rooms and equipped with the latest original analytical equipment including a high-performance processor with a special program management, developed in the company before the said projects

The following are examples of analytical findings and conclusions:
1. The technology is capable of resonance control with the necessary precision to distinguish between themselves by a combined integrated indicator patterns of technological solutions and liquids in various areas of industrial and agricultural production, including, for example - whole milk in elementary, middle, and final phases of the milking process, which is not possible with any currently existing technology;
2. The technology is capable of resonance control with the necessary precision to distinguish between themselves by a combined integrated indicator different technological solutions and liquids at different stages and phases of production, or at different stages of the production or storage, or transportation, and as such - the samples of whole milk in the primary, middle and final stages of the milking process and may differ from each other are the same patterns that have different periods of storage at room temperature;
3. The technology is capable of resonance control with the necessary precision to distinguish between themselves by a combined integrated indicator various liquids and solutions are introduced into the ionic form of materials and components, such as heavy metal ions, the ions of precious metals, radioactive metal ions, or samples of whole milk in elementary, middle, and final phases of the milking process and can distinguish between a same samples that have different periods of storage at room temperature, and which additionally introduced certain doses of blood;
4. The technology is capable of resonance control with the necessary precision to distinguish from each other in the integral composite index as an example of the unique and extreme sensitivity, samples of whole milk in elementary, middle, and final phases of the milking process and can distinguish between a same samples that have different periods of storage at room temperature and which introduced certain additional dose of glucose;
5. The technology is capable of resonance control with the necessary precision to distinguish from each other in the integral composite index as an example of the unique, unusual and extreme sensitivity and accuracy, samples of whole milk in elementary, middle, and final phases of the milking process and may differ from each other are the same patterns that have different of storage at room temperature and which introduced certain additional dose of urea;
6. The technology is capable of resonance control with the necessary precision to distinguish from each other in the integral composite index as an example of the uniqueness and accuracy, as an example of the precision and selectivity selectivity - samples of whole milk in elementary, middle, and final phases of the milking process and can distinguish between a same samples, which have different periods of storage at room temperature, and which additionally introduced certain doses of milk fat;
7. The technology is capable of resonance control with the necessary precision to distinguish between themselves by a combined integrated indicator liquids and solutions without biologically active components, and the same fluid with the introduction of these biological components, and as an example - the samples of whole milk in elementary, middle, and final phases of the process milking with different concentration levels of somatic cells and can differentiate between a same samples that have different periods of storage at room temperature;
8. The technology is capable of resonance control with the necessary precision to distinguish between themselves by a combined integrated indicator fluid samples with ingredients like organic and inorganic origin, with a combination of biological structures and units, including whole milk in elementary, middle, and final phases of the milking process with different concentration levels of somatic cells and can differentiate between a same samples that have different periods of storage at room temperature and in parallel can evaluate and distinguish, for example, the acidity of the same samples of liquids, including milk;
9. Experiments have confirmed the appropriateness of the pre-test strategy, of at least two-stage resonance sensor calibration, - in the first stage at the level of the integrated signal based on characteristics empidansnyh phenomena in liquid or solution, and the second stage at the selective isolation of the most contrasting combination resonance manifest - frequency and amplitude of complex reservoir characteristics in the test samples of all types of liquids, including milk and data for each of the monitored parameters and characteristics;
10. In general, the system showed high sensitivity to give signals, high selectivity for the separation and comparison of signals sufficient repeatability, stable operation of the accepted methods of sufficient accuracy in determining the integral components of the signals of sufficient autonomy and independence to external shocks and disturbances, the possibility for the operator stable, sustainable and profitable management of the system without special formal training;
11. Preliminary studies provide a basis for concluding that the possibility of the next phases of the projects go to applique selective control of all necessary parameters of liquids, process solutions, waste water, drinking water, food and liquid products to a fundamental design of all required applications of resonant sensors;
12. Results for configuration and change the operating parameters of sensors, the general nature of the process control and digital testing the sensor and its entire infrastructure, suggests the possibility of steady guaranteed distantsionnogno management of the sensors, sensor synchronization groups of their basic measurement and analytical functions and the ability to adapt sensors to according to the characteristics and different conditions in all areas of production and defense - strategic areas, in addition, the unique capabilities of the technology, allow its use, for example, dairy farms and the dairy and food industry

To be continued ....